I was going to write a blog entry on the subject, citing scripture, that the prophets warned of the danger of God's cursing both individuals and humanity as a whole, when I found a scriptural writing that expressed it in a very clear to understand way. Read the page at this link.
As the author writes, it must remain very sobering that the last word of the last of the Old Testament prophets is "curse."
God can and does curse individuals for their disobedience to him. The curse may be revealed as punishment during life or upon the individual's death and arrival for final judgment.
Do not be presumptuous.